Larry Fitzgerald (ankle) and Andre Ellington (knee) are probable against the Niners while Michael Floyd (hamstring) is questionable. On the other side of the line, Carlos Hyde (foot) is out.
Leonard Hankerson (hamstring) and Devonta Freeman (concussion) are out for Atlanta facing the Vikings, who are essentially at full strength.
Tyrod Taylor (shoulder) is probable for the Bills facing the Chiefs, for whom Travis Kelce (groin) is questionable but expected to play while Charcandrick West (hamstring) is questionable but not expected to suit up.
Owen Daniels (knee) and Emmanuel Sanders (ankle) are both probable for the Broncos facing the Patriots, with Danny Amendola (knee) is not making the trip.
Andy Dalton (groin) and Marvin Jones (hamstring) are probable facing the Rams, who have Greg Zuerlein (groin) as questionable but he did travel with the team.
The red-hot Texans have Brian Hoyer (concussion) as probable with Alfred Blue (back) probable going against the Saints, who have Mark Ingram (shoulder) and Willie Snead (knee) as probable.
Andrew Luck (kidney) is out with Frank Gore (ankle) probable versus Tampa Bay, who are at full strength.
Allen Hurns (thigh) is probable facing the Chargers, who have Antonio Gates (hip) and Malcom Floyd (shoulder) probable.
Jarvis Landry (knee) is questionable but expected to be active for the Dolphins facing the Jets, who have Ryan Fitzpatrick (thumb), Brandon Marshall (toe) and Eric Decker (knee) listed as probable.
Tight End Larry Donnell (neck) is out for the Giants facing the Skins, who have Alfred Morris (rib) probable.
The Raiders have no major question marks going against the Titans, who are similarly at pretty much full strength.
Pittsburgh will tough it out with no reported injuries facing the Seahawks, who have Marshawn Lynch (abdoman) out with Thomas Rawls (knee) and Doug Baldwin (ankle) listed as probable.
With injuries to Joe Flacco and Justin Forsett, the Ravens will look to Matt Schaub at QB, with Javorius Allen topping the RB's Monday night against the Browns where Josh McCown is probable.
Keenan Allen, Jamaal Charles, Jordy Nelson, Le'Veon Bell, Victor Cruz, Andrew Luck, Tony Romo, Julian Edelman, Joe Flacco, Justin Forsett, Steve Smith, Peyton Manning and metaphorically, Johnny Manziel.
With the fragile Mr. Amendola hurting in New England, Brandon LaFell makes a good lower priced play, as does underrated Dwayne Harris at WR this week for the Giants.
For the second week in a row, I am gambling that Ryan Fitzpatrick will take care of the basics facing a Dolphins defense that has been erratic, and finally, I am sold that the Chiefs defense at home facing the Bills will take care of business.
In the "there is always hope" department, Reid Brignac, who was going to be the next big thing in the Rays' infield way back when, signed a minor league deal with the Braves.
On the other hand, J.P. Arencibia was again released. Easy come, easy go.
Again, remember you can play against us at the Mastersball 50-team 50/50 Challenge and you can follow me @lawrmichaels.